Spatial distribution of cervical cancer cases diagnosed in Gaborone, Botswana
I am a third year doctoral student in Epidemiology at the University of Pennsylvania, Perelman School of Medicine. I have done extensive work in the field of oncology investigating genetics, risk factors, early detection, and prevention efforts to reduce the morbidity and mortality of breast, ovarian, cervical, and prostate cancers. I have also collaborated with multiple international consortiums and have conducted research in the United States, Senegal, and Botswana. My current dissertation work focuses on identifying clinical, sociodemographic, and geo-spatial factors associated with late stage at diagnosis of cervical cancer for women in Botswana. I aspire to become an independent researcher in academia with a focus on global oncology.
Background: Geographic Information systems (GIS) are a powerful tool for understanding health patterns that can help identify areas in need of public health intervention. This approach could particularly benefit Botswana, a low resource setting with high cervical cancer (CC) mortality characterized by a large geographic area and a dispersed population limited to one CC treatment facility located in Gaborone.
Methods: Merging publicly available geographic data together with CC residential data from a large cohort study at Princess Marina Hospital (PMH) in Gaborone, we aimed to identify geographic patterns of CC cases using Global Moran’s I and Anselin Local Moran’s I values (ArcMap 10.6.1), to test if the spatial distribution of CC rates was random. Villages with significantly higher (H) or lower (L) rates than expected were designated as HH/LL clusters or HL/LH outliers. Chi-square tests and t-tests identified differences among the clusters/outliers.
Results: There were 1033 women were diagnosed with CC at PMH between 2015 and 2020. We identified a non-random distribution of CC rates across Botswana (p <0.001). Local Moran’s I identified 83 HH clusters, 75 LL clusters, 25 HL outliers, and 61 LH outliers. Individual characteristics of CC cases such as age, HIV status, and proximity to PMH were different among the clusters.
Conclusions: We identified non-random patterns of CC rates throughout Botswana. Importantly, high and low clusters could help identify areas for implementing public health interventions, i.e. screening programs. Next steps will be to assess CC knowledge, screening and healthcare systems in these villages.
KeywordsGIS, spatial analysis, cervical cancer, global health, Botswana
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